PROTEIN EXPRESSION APPLICATIONS

Protein expression is a crucial tool for both production and study of proteins. Cell lines optimized for protein expression are used to manufacture therapeutics and also to study the inner workings of cells.

• Antibodies: Antibodies manufactured in genetically-modified cells are a important therapeutic and research tool, such as in this study, where a baculovirus vector was used to express a high-affinity chimeric antibody for CD19. This antibody is a potential treatment for leukemia.
• Gene Therapy: Cell lines are used to manufacture shRNA-producing vectors for gene silencing as well as other gene therapeutics.
• Vaccines: Recombinant organisms are used to produce both immune-activating proteins and virus-like particles. In this example, virus-like proteins that mimic murine polyomavirus are manufactured in both yeast and bacteria and compared for effectiveness.
• Cell Research: Cells modified for protein expression can be used to study intra and extra-cellular signaling, protein-protein interactions, folding and structural biology. An example of protein expression used to study cell signaling can be found in this study, which used murine vascular cells designed to under- and over-express TGFβ to study signaling pathways that may play a role in ocular diseases.

FOR MORE INFORMATION, SEE:

• Request quote for:
  • ELISA
  • Western Blot
  • Other Laboratory Services(Xenograft, RNAi, Stable Cell Lines)
• Protein Expression Services
• Protein Expression Applications
• Assay Development
• ELISA
• Western Blot
• Stability Analysis

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